Reactome | The small GTPase Rab5 regulates membrane traffic into and be...

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created	[InstanceEdit:1011596] Jupe, S, 2010-11-11
dbId	1011603
displayName	The small GTPase Rab5 regulates membrane traffic into and be...
literatureReference	[LiteratureReference:1011574] Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11 [LiteratureReference:1011609] Phosphatidylinositol-3-OH kinases are Rab5 effectors
schemaClass	Summation
text	The small GTPase Rab5 regulates membrane traffic into and between early endosomes by specifically recruiting cytosolic effector proteins to their site of action on early endosomal membranes. Rab5 occupies a restricted membrane subdomain on endosomes that has distinct biochemical features when compared with neighboring subcompartments (Sonnichsen et al. 2000). Rab5 is believed to form this subdomain by recruiting the specific PI3 kinase VPS-45, causing localized production of PI-3-phosphate (PI-3P) (Christoforidis et al. 1999). Rabenosyn-5 is a Rab5 effector, recruited in a phosphatidylinositol-3-kinase dependent fashion to early endosomes where it serves as a molecular link between VPS-45 and Rab5.

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