PathIntegrate: Multivariate modelling approaches for pathway-based multi-omics data integration

In PLOS Computational Biology, Wieder et al. (2024) employ the Reactome database and PathIntegrate, a pathway-based multi-omics integration tool based on single-sample pathway analysis and machine learning, to translate multi-omics datasets from molecular abundance measurements to pathway activity scores, enabling integration of disparate types of omics data according to a common scale. PathIntegrate provides higher sensitivity at low signal levels and efficiently identifies perturbed pathways from multi-omics datasets in COVID-19 and chronic obstructive pulmonary disease (COPD) examples, providing a readily interpretable predictive model.