Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer

In the May 2024 issue of NPJ Precision Oncology, Cyberski et al. used Reactome’s hierarchically arranged pathways with their in silico Pathway Activation Network Decomposition Analysis (iPANDA) algorithm to identify upregulation of networks associated with cell cycle progression, signal transduction, and metabolism and down-regulation of immune cellular process and apoptosis in MYC-amplified cases of recurrent/metastatic head and neck squamous cell carcinoma.