In the November 2023 issue of Cell Communication and Signaling, Bukva et al. (2023) analyzed the proteomes of tumor-produced extracellular vesicles and identified sets of proteins that could discriminate tumor types, invasiveness, and proliferative capacity. In this analysis, 172 most predictive proteins were identified and used to classify nine tumor types with 91.67% efficiency. Reactome Pathway enrichment analysis of these proteins showed that each tumor type had perturbations in a distinct set of pathways. The proteins could be organized and used to discriminate the invasiveness and proliferative capacity of the tumors. High expression of proteins positively associated with invasiveness and proliferation correlated with reduced patient survival times.