New Insights into Clinical Management for Sickle Cell Disease: Uncovering the Significant Pathways Affected by the Involvement of Sickle Cell Disease

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In the chapter entitled “New Insights into Clinical Management for Sickle Cell Disease: Uncovering the Significant Pathways Affected by the Involvement of Sickle Cell Disease”, published in Methods in Molecular Biology 2024, Chouhan et al. describe the use of Reactome FIviz Cytoscape plugin to analyze pathway enrichment and construct a functional interaction network for DisGNET-derived sickle cell disease-associated genes, identifying genes involved in “Glucuronidation”, “Aspirin ADME”, “Phase II-Conjugation of compounds”, “Interleukin-4 and interleukin-13 signaling”, “Interleukin-10 signaling”, “Signaling by interleukins”, “Biological oxidations”, and “Cytokine signaling in immune system”.