DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study

In the August 2, 2023 issue of Clinical Epigenetics, Miller et al. performed an epigenome-wide association study using Reactome Functional Interaction network analysis and determined that DNA methylation at loci involved in calcium channel activity and development was associated with long-term cardiovascular disease risk beyond known risk factors in type 1 diabetes, particularly in individuals with greater glycemic exposure.