Severe COVID-19 in pregnancy has a distinct serum profile, including greater complement activation and dysregulation of serum lipids

Pregnancies complicated by Coronavirus Disease 2019 (COVID-19) are at an increased risk of severe morbidity. In multi-omics analyses investigating the pathophysiology behind severe COVID-19 disease, Altendahl et al, in the November 2022 issue of PLoS One found precipitous changes in maternal serum in those with severe COVID-19 infection. Reactome pathway enrichment analysis revealed upregulated analytes in 4 pathways: Complement cascade, Signaling by the B Cell Receptor (BCR), Fc epsilon receptor (FCERI) signaling, and FCGR activation.