Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP‐1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates

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Tagliazucchi L et al. 2023 in the March 2023 issue of ACS Infectious Diseases used the REACTOME overrepresentation and pathway topology analyses to identify Transport of small molecules, Cellular response to stress and other pathways associated with drug resistance and therapeutic failure (TF) during Leishmania infantum infection; they also discovered NDK3 and TFRC as potential targets for host-directed anti-Leishmania therapies to overcome drug-resistance.