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alkal1 [extracellular region]
Stable Identifier
R-XTR-9842576
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
extracellular region
Synonyms
ALKAL1, A0A803JK80
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
ALK autophosphorylation (Xenopus tropicalis)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
ALK binds ALKAL ligand (Xenopus tropicalis)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK binds JAK3 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK binds PLCG1 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK dimer binds IRS1 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates IRS1 (Xenopus tropicalis)
Active ALK:IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:pY-IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates JAK3 (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:p-Y980 JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates PLCG1 (Xenopus tropicalis)
Active ALK:PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:p-4Y PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates SHC1 (Xenopus tropicalis)
Active ALK:SHC1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:p-3Y SHC1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK recruits PI3K (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Liganded-ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
PTPN6 dephosphorylates JAK3 (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active ALK:p-Y980 JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
STAT3 is phosphorylated downstream of active ALK (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Xenopus tropicalis)
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Signaling by LTK (Xenopus tropicalis)
Active LTK binds IRS1 (Xenopus tropicalis)
Active LTK:IRS1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK phosphorylates IRS1 (Xenopus tropicalis)
Active LTK:IRS1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK:p-Y IRS1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK receptor binds PI3K (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK receptor phosphorylates SHC1 (Xenopus tropicalis)
Active LTK:SHC1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK:p-3Y SHC1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK recruits GRB2:SOS1 (Xenopus tropicalis)
Active LTK:p-3Y SHC1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Autophosphorylation of LTK dimer:ALKAL1,2 (Xenopus tropicalis)
LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
IRS1 recruits GRB2 to active LTK (Xenopus tropicalis)
Active LTK:p-Y IRS1 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
Active LTK:p-Y IRS1:GRB2 [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
LTK binds ALKAL ligand (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
LTK dimer:ALKAL1,2 [plasma membrane] (Xenopus tropicalis)
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
alkal1 [extracellular region] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A803JK80
Gene Names
alkal1
Reference Genes
BioGPS Gene:100487397 alkal1
ENSEMBL:ENSXETG00000041022
KEGG:xtr:100487397 alkal1
Monarch:100487397 alkal1
NCBI Gene:100487397 alkal1
UCSC:A0A803JK80 alkal1
Reference Transcript
RefSeq:XM_031904549.1 alkal1
Other Identifiers
100487397
GO:0005125
GO:0005576
GO:0007165
GO:0030298
GO:0030971
GO:0048018
GO:0070374
GO:0070378
GO:0098772
Participates
as a member of
ALKAL1,2 [extracellular region] (Xenopus tropicalis)
as a candidate of
ALKAL2:(ALKAL1) [extracellular region] (Xenopus tropicalis)
Inferred From
ALKAL1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_031760409.1
ENSEMBL
ENSXETG00000041022
,
ENSXETT00000122589
,
ENSXETP00000108356
Xenbase
XB-GENE-6043666
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