Reactome | asb2 [cytosol]

asb2 [cytosol]

Stable Identifier

R-XTR-975423

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

ASB2, F6UE08

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Xenopus tropicalis)
        
        ASB family [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        asb2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6UE08

Gene Names

asb2

Reference Genes

BioGPS Gene:100490014 asb2

ENSEMBL:ENSXETG00000010311

KEGG:xtr:100490014 asb2

Monarch:100490014 asb2

NCBI Gene:100490014 asb2

UCSC:F6UE08 asb2

Reference Transcript

RefSeq:XM_002933230.5 asb2

Other Identifiers

100490014

GO:0005634

GO:0005737

GO:0016567

GO:0035556

GO:2000812

Participates

as a member of

Inferred From

ASB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002933276.2

ENSEMBL

ENSXETG00000010311, ENSXETP00000022701, ENSXETT00000022701

Xenbase

XB-GENE-983015

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