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cul3 [cytosol]
Stable Identifier
R-XTR-8952516
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
G76-NEDD8-K712-CUL3, A4IHP4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
KEAP1-NFE2L2 pathway (Xenopus tropicalis)
CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Xenopus tropicalis)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Xenopus tropicalis)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
RBX1:CUL3 dissociates from forming autophagosome (Xenopus tropicalis)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Xenopus tropicalis)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Xenopus tropicalis)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Xenopus tropicalis)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Neddylation (Xenopus tropicalis)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Xenopus tropicalis)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
cul3 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A4IHP4
Gene Names
cul3
Reference Genes
BioGPS Gene:548729 cul3
ENSEMBL:ENSXETG00000008183
KEGG:xtr:548729 cul3
Monarch:548729 cul3
NCBI Gene:548729 cul3
UCSC:A4IHP4 cul3
Reference Transcript
RefSeq:NM_001015975.3 cul3
Other Identifiers
548729
GO:0000209
GO:0000278
GO:0000922
GO:0003824
GO:0004842
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005827
GO:0006511
GO:0006513
GO:0006888
GO:0006915
GO:0006950
GO:0007080
GO:0007165
GO:0007229
GO:0010468
GO:0010558
GO:0016192
GO:0016477
GO:0016567
GO:0016740
GO:0017145
GO:0030163
GO:0031461
GO:0031463
GO:0031625
GO:0035024
GO:0040016
GO:0043149
GO:0043161
GO:0043226
GO:0045842
GO:0046872
GO:0048208
GO:0048870
GO:0051301
GO:0065003
GO:0072686
GO:0080090
GO:0140096
GO:1901992
Participates
as a component of
NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Xenopus tropicalis)
Other forms of this molecule
cul3 [nucleoplasm]
cul3 [cytosol]
Inferred From
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 712 (in Homo sapiens)
Coordinate
712
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_001015975.2
ENSEMBL
ENSXETG00000008183
,
ENSXETT00000017945
,
ENSXETP00000017945
Xenbase
XB-GENE-974982
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