Reactome | Ghost homologue of NBN [nucleoplasm]

Ghost homologue of NBN [nucleoplasm]

Stable Identifier

R-XTR-75163

Type

Genes and Transcripts [GenomeEncodedEntity]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Xenopus tropicalis)

- DNA Double-Strand Break Repair (Xenopus tropicalis)
  - Homology Directed Repair (Xenopus tropicalis)
    - HDR through MMEJ (alt-NHEJ) (Xenopus tropicalis)
      - FEN1 cleaves displaced ssDNA flaps during MMEJ (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
      - MRN and RBBP8 resect DNA DSBs in MMEJ (Xenopus tropicalis)
        
        DNA DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        DNA DSBs:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
      - MRN recruits LIG3:XRCC1 to MMEJ sites (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
      - PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
      - PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
      - POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Xenopus tropicalis)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Xenopus tropicalis)
        
        MRN [nucleoplasm] (Xenopus tropicalis)
        
        Ghost homologue of NBN [nucleoplasm] (Xenopus tropicalis)

Participates

as a component of

MRN [nucleoplasm] (Xenopus tropicalis)

Inferred From

NBN [nucleoplasm] (Homo sapiens)

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