Reactome | rpl18a [cytosol]

rpl18a [cytosol]

Stable Identifier

R-XTR-72422

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RPL18A, F6Y9Q4

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)
- rRNA processing (Xenopus tropicalis)
  - rRNA processing in the nucleus and cytosol (Xenopus tropicalis)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Xenopus tropicalis)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rpl18a [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6Y9Q4

Gene Names

rpl18a

Reference Genes

BioGPS Gene:549444 rpl18a

ENSEMBL:ENSXETG00000021667

KEGG:xtr:549444 rpl18a

Monarch:549444 rpl18a

NCBI Gene:549444 rpl18a

UCSC:F6Y9Q4 rpl18a

Reference Transcript

RefSeq:NM_001016690.2 rpl18a

Other Identifiers

549444

GO:0002181

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0022625

GO:1990904

Participates

as a component of

Inferred From

RPL18A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001016690.1

ENSEMBL

ENSXETP00000046845, ENSXETG00000021667, ENSXETT00000046845

Xenbase

XB-GENE-5774784

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