Reactome | ptbp1 [nucleoplasm]

ptbp1 [nucleoplasm]

Stable Identifier

R-XTR-71923

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

PTBP1, Q5XGH0

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Processing of Capped Intron-Containing Pre-mRNA (Xenopus tropicalis)
  - Formation of pre-mRNPs (Xenopus tropicalis)
    - Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
      - ptbp1 [nucleoplasm] (Xenopus tropicalis)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Xenopus tropicalis)
      - Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
  - mRNA 3'-end processing (Xenopus tropicalis)
    - mRNA Polyadenylation (Xenopus tropicalis)
      - Core CPA complex binds capped pre-mRNA (Xenopus tropicalis)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
      - PP1 dephosphorylates RNA Pol II (Xenopus tropicalis)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
      - RBBP6 activates CPSF complex (Xenopus tropicalis)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
  - mRNA Splicing (Xenopus tropicalis)
    - mRNA Splicing - Major Pathway (Xenopus tropicalis)
      - Formation of the Spliceosomal C complex containing intron lariat (Xenopus tropicalis)
        
        Spliceosomal B* complex [nucleoplasm] (Xenopus tropicalis)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal C complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
      - Formation of the Spliceosomal P complex and exon ligation (Xenopus tropicalis)
        
        Spliceosomal C* complex [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)
        
        Spliceosomal P complex [nucleoplasm] (Xenopus tropicalis)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Xenopus tropicalis)
        
        Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)
        
        ptbp1 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q5XGH0

Gene Names

ptbp1

Reference Genes

BioGPS Gene:496557 ptbp1

ENSEMBL:ENSXETG00000021661

KEGG:xtr:496557 ptbp1

Monarch:496557 ptbp1

NCBI Gene:496557 ptbp1

UCSC:Q5XGH0 ptbp1

Reference Transcript

RefSeq:NM_001011140.1 ptbp1

Other Identifiers

496557

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0006397

GO:0008380

GO:0010467

GO:0010629

GO:0016071

GO:0043484

GO:0045595

GO:1903312

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Xenopus tropicalis)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)

as a component of

FGFR2 IIIc-specific splicing complex [nucleoplasm] (Xenopus tropicalis)

Inferred From

PTBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001011140.1

ENSEMBL

ENSXETT00000046826, ENSXETG00000021661, ENSXETP00000046826

Xenbase

XB-GENE-5818206

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