Reactome | gtf2h2 [nucleoplasm]

gtf2h2 [nucleoplasm]

Stable Identifier

R-XTR-65914

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

GTF2H2, Q5XGG8

Locations in the PathwayBrowser

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DNA Repair (Xenopus tropicalis)

- Nucleotide Excision Repair (Xenopus tropicalis)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
    - Formation of Incision Complex in GG-NER (Xenopus tropicalis)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH Core [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH Core [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - Recruitment of XPA and release of CAK (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH Core [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - SUMOylation of XPC (Xenopus tropicalis)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH Core [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH Core [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
    - Dual incision in TC-NER (Xenopus tropicalis)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)
        
        TC-NER incision complex [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
        
        TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
    - Formation of TC-NER Pre-Incision Complex (Xenopus tropicalis)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - Assembly of the pre-incision complex in TC-NER (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - ERCC6 binds stalled RNA Pol II (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - ERCC8 (CSA) binds stalled RNA Pol II (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
      - UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
        
        TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Xenopus tropicalis)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        TFIIH [nucleoplasm] (Xenopus tropicalis)
        
        gtf2h2 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q5XGG8

Gene Names

gtf2h2

Reference Genes

BioGPS Gene:496493 gtf2h2

ENSEMBL:ENSXETG00000026187

KEGG:xtr:496493 gtf2h2

Monarch:496493 gtf2h2

NCBI Gene:496493 gtf2h2

UCSC:Q5XGG8 gtf2h2

Reference Transcript

Other Identifiers

496493

GO:0000439

GO:0005634

GO:0005675

GO:0006281

GO:0006289

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0008270

GO:0016607

GO:0046872

Participates

as a component of

Inferred From

GTF2H2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_012816146.1, NP_001011081.1

ENSEMBL

ENSXETP00000055346, ENSXETG00000026187, ENSXETT00000055346

Xenbase

XB-GENE-1002369

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