Reactome | cyfip1 [cytosol]

cyfip1 [cytosol]

Stable Identifier

R-XTR-5672575

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

CYFIP1, A0A8J0R136

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Innate Immune System (Xenopus tropicalis)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
    - Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
      - ABL phosphorylates WAVEs (Xenopus tropicalis)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
      - Detachment of WASP/WAVE (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
      - p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase Effectors (Xenopus tropicalis)
      - RHO GTPases Activate WASPs and WAVEs (Xenopus tropicalis)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        ABL phosphorylates WAVEs (Xenopus tropicalis)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        Detachment of WASP/WAVE (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
        
        p-Y,S,T-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
    - RHO GTPase cycle (Xenopus tropicalis)
      - RAC2 GTPase cycle (Xenopus tropicalis)
        
        RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RAC2 plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        WAVE2 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Xenopus tropicalis)
        
        RAC2 plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        WAVE2 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
      - RAC3 GTPase cycle (Xenopus tropicalis)
        
        RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RAC3 effectors [cytosol] (Xenopus tropicalis)
        
        WAVE1 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        RAC3:GTP:RAC3 effectors [plasma membrane] (Xenopus tropicalis)
        
        RAC3 effectors [cytosol] (Xenopus tropicalis)
        
        WAVE1 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        WAVE2 Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
      - RHOG GTPase cycle (Xenopus tropicalis)
        
        RHOG binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        cyfip1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A8J0R136

Gene Names

cyfip1

Reference Genes

BioGPS Gene:101734874 cyfip1

ENSEMBL:ENSXETG00000004138

KEGG:xtr:101734874 cyfip1

Monarch:101734874 cyfip1

NCBI Gene:101734874 cyfip1

UCSC:A0A8J0R136 cyfip1

Reference Transcript

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)

as a component of

as a member of

CYFIP1,CYFIP2 [cytosol] (Xenopus tropicalis)

Other forms of this molecule

cyfip1 [secretory granule lumen]

cyfip1 [specific granule lumen]

cyfip1 [extracellular region]

cyfip1 [tertiary granule lumen]

Inferred From

CYFIP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_004911870.1, XP_004911869.1

Xenbase

XB-GENE-1194389

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