Reactome | GNAQ [plasma membrane]

GNAQ [plasma membrane]

Stable Identifier

R-XTR-55453

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

K9J7P8

Locations in the PathwayBrowser

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Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to mechanical stimuli (Xenopus tropicalis)
  - Response of endothelial cells to shear stress (Xenopus tropicalis)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Xenopus tropicalis)
      - Phosphorylation of PDPK1 on serine-241 (Xenopus tropicalis)
        
        G-protein alpha (q/11) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)

Hemostasis (Xenopus tropicalis)

- Platelet activation, signaling and aggregation (Xenopus tropicalis)
  - Signal amplification (Xenopus tropicalis)
    - ADP signalling through P2Y purinoceptor 1 (Xenopus tropicalis)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Xenopus tropicalis)
        
        G protein alpha:GTP complex [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)
    - Thromboxane signalling through TP receptor (Xenopus tropicalis)
      - Gq activation by TP receptor (Xenopus tropicalis)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Xenopus tropicalis)
        
        G protein-GTP [plasma membrane] (Xenopus tropicalis)
        
        G protein alpha:GTP complex [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Xenopus tropicalis)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)
  - Thrombin signalling through proteinase activated receptors (PARs) (Xenopus tropicalis)
    - Thrombin-activated PARs activate Gq (Xenopus tropicalis)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Xenopus tropicalis)
        
        G protein-GTP [plasma membrane] (Xenopus tropicalis)
        
        G protein alpha:GTP complex [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Xenopus tropicalis)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Xenopus tropicalis)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Xenopus tropicalis)
        
        GNAQ [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:K9J7P8

Reference Genes

BioGPS Gene:733773

ENSEMBL:ENSXETG00000003621

KEGG:xtr:733773

Monarch:733773

NCBI Gene:733773

UCSC:K9J7P8

Reference Transcript

RefSeq:NM_001044517.1

Other Identifiers

733773

GO:0000166

GO:0001664

GO:0001750

GO:0003924

GO:0005096

GO:0005525

GO:0005737

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0007189

GO:0007213

GO:0007215

GO:0007603

GO:0009649

GO:0016020

GO:0016787

GO:0019001

GO:0031683

GO:0045202

GO:0046872

GO:0098772

Participates

as a member of

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Xenopus tropicalis)

Inferred From

GNAQ [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001037982.1

ENSEMBL

ENSXETP00000007815, ENSXETG00000003621, ENSXETT00000007815

Xenbase

XB-GENE-973433

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