Reactome | mta2 [nucleoplasm]

mta2 [nucleoplasm]

Stable Identifier

R-XTR-4657009

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

MTA2, A0A8J0QXV1

Locations in the PathwayBrowser

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Chromatin organization (Xenopus tropicalis)

- ATP-dependent chromatin remodelers (Xenopus tropicalis)
  - CHD chromatin remodelers (Xenopus tropicalis)
    - CHD3, CHD4, CHD5 subfamily (Xenopus tropicalis)
      - NuRD complex assembly (Xenopus tropicalis)
        
        CHD and CDK2AP subunits are recruited to NuRD (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, 2 bind MTA1, 2, 3 and RBBP4,7 (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        Interaction of NuRD complexes with transcription factors (Xenopus tropicalis)
        
        GATAD2A NuRD binds ZMYND8:ZNF532:ZNF592:ZNF687 (Xenopus tropicalis)
        
        GATAD2A NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        ZMYND8:ZNF532:ZNF592:ZNF687:GATAD2A NuRD [nucleoplasm] (Xenopus tropicalis)
        
        GATAD2A NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD binds Ikaros family member proteins (Xenopus tropicalis)
        
        IKZF1,IKZF2,IKZF3:NuRD [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD binds TCF19 at FBP1 gene (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        TCF19:NuRD:FBP1 gene:H3K4 nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD binds TCF19 at G6PC gene (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        TCF19:NuRD:G6PC gene:H3K4 nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD binds TCF19 at PCK1 gene (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        TCF19:NuRD:PCK1 gene:H3K4 nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD deacetylates telomeric nucleosomes (Xenopus tropicalis)
        
        NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NR2C2,NR2F2:ZNF827:NuRD:telomeric chromatin [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        PHF6 binds NuRD (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        PHF6:NuRD [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        ZNF827 and NR2C2,NR2F2 recruit NuRD to telomeric chromatin (Xenopus tropicalis)
        
        NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        NuRD [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
- Chromatin modifying enzymes (Xenopus tropicalis)
  - HDACs deacetylate histones (Xenopus tropicalis)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)
      - HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
    - HDAC1:2-containing complex deacetylate histones (Xenopus tropicalis)
      - HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Xenopus tropicalis)
        
        HDAC1:2-containing complex [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - Regulation of TP53 Activity (Xenopus tropicalis)
        
        Regulation of TP53 Activity through Acetylation (Xenopus tropicalis)
        
        MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)
        
        MTA2-NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Intracellular signaling by second messengers (Xenopus tropicalis)
  - PIP3 activates AKT signaling (Xenopus tropicalis)
    - PTEN Regulation (Xenopus tropicalis)
      - Regulation of PTEN gene transcription (Xenopus tropicalis)
        
        SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Xenopus tropicalis)
        
        SALL4:NuRD [nucleoplasm] (Xenopus tropicalis)
        
        NuRD complex [nucleoplasm] (Xenopus tropicalis)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)
        
        mta2 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A8J0QXV1

Gene Names

mta2

Reference Genes

BioGPS Gene:100126057 mta2

ENSEMBL:ENSXETG00000005633

KEGG:xtr:100126057 mta2

Monarch:100126057 mta2

NCBI Gene:100126057 mta2

UCSC:A0A8J0QXV1 mta2

Reference Transcript

RefSeq:XM_002941462.5 mta2

Participates

as a component of

MTA2-NuRD complex [nucleoplasm] (Xenopus tropicalis)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Xenopus tropicalis)

Inferred From

MTA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_002941508.2

Xenbase

XB-GENE-947630

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