Reactome | sptbn2 [cytosol]

sptbn2 [cytosol]

Stable Identifier

R-XTR-420049

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

SPTBN2, A0A8J0SD73

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - NCAM signaling for neurite out-growth (Xenopus tropicalis)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Xenopus tropicalis)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Asparagine N-linked glycosylation (Xenopus tropicalis)
    - Transport to the Golgi and subsequent modification (Xenopus tropicalis)
      - ER to Golgi Anterograde Transport (Xenopus tropicalis)
        
        COPI-mediated anterograde transport (Xenopus tropicalis)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Xenopus tropicalis)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Xenopus tropicalis)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- MAPK family signaling cascades (Xenopus tropicalis)
  - MAPK1/MAPK3 signaling (Xenopus tropicalis)
    - RAF/MAP kinase cascade (Xenopus tropicalis)
      - RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
        
        RAS GEFs [plasma membrane] (Xenopus tropicalis)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Xenopus tropicalis)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - ER to Golgi Anterograde Transport (Xenopus tropicalis)
    - COPI-mediated anterograde transport (Xenopus tropicalis)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Xenopus tropicalis)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Xenopus tropicalis)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Xenopus tropicalis)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Xenopus tropicalis)
        
        Spectrin tetramer [cytosol] (Xenopus tropicalis)
        
        SPTA:SPTB [cytosol] (Xenopus tropicalis)
        
        Spectrin beta chain [cytosol] (Xenopus tropicalis)
        
        sptbn2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A8J0SD73

Gene Names

sptbn2

Reference Genes

BioGPS Gene:100486199 sptbn2

ENSEMBL:ENSXETG00000015170

Monarch:100486199 sptbn2

NCBI Gene:100486199 sptbn2

UCSC:A0A8J0SD73 sptbn2

Reference Transcript

RefSeq:XM_012962405.3 sptbn2

Participates

as a member of

Spectrin beta chain [cytosol] (Xenopus tropicalis)

Inferred From

SPTBN2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012817859.1

Xenbase

XB-GENE-1008690

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