Reactome | phospho-p-Y596,Y602-EPHA4 [plasma membrane]

phospho-p-Y596,Y602-EPHA4 [plasma membrane]

Stable Identifier

R-XTR-3928352

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

F6QKP3

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH receptors autophosphorylate (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        EPHA binds TIAM1 (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)
      - EPHA-mediated growth cone collapse (Xenopus tropicalis)
        
        NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y596,Y602-EPHA4 [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6QKP3

Reference Genes

BioGPS Gene:100216124

ENSEMBL:ENSXETG00000007614

Monarch:100216124

NCBI Gene:100216124

UCSC:F6QKP3

Reference Transcript

RefSeq:XM_012970177.2

Other Identifiers

100216124

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005005

GO:0005524

GO:0005768

GO:0005769

GO:0005886

GO:0007155

GO:0007169

GO:0007399

GO:0007411

GO:0016020

GO:0016301

GO:0016740

GO:0030425

GO:0048013

GO:0048856

GO:0140096

Participates

as a member of

p-EPHAs [plasma membrane] (Xenopus tropicalis)

Other forms of this molecule

EPHA4 [plasma membrane]

Inferred From

p-Y596,Y602-EPHA4 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 596 (in Homo sapiens)

Coordinate

596

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 602 (in Homo sapiens)

Coordinate

602

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_012825631.1

ENSEMBL

ENSXETP00000016595, ENSXETT00000016595, ENSXETG00000007614

Xenbase

XB-GENE-1015803

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