Reactome | phospho-p-Y594,Y600-EPHB1 [plasma membrane]

phospho-p-Y594,Y600-EPHB1 [plasma membrane]

Stable Identifier

R-XTR-3928347

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

A0A6I8R958

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH receptors autophosphorylate (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
      - EPHB-mediated forward signaling (Xenopus tropicalis)
        
        EPHB phosphorylates TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB phosphorylates SDC2 (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs:EFNBs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHBs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y594,Y600-EPHB1 [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8R958

Reference Genes

BioGPS Gene:493336

ENSEMBL:ENSXETG00000013722

KEGG:xtr:493336

Monarch:493336

NCBI Gene:493336

UCSC:A0A6I8R958

Reference Transcript

RefSeq:XM_002935075.4

Other Identifiers

493336

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005005

GO:0005524

GO:0005768

GO:0005886

GO:0007155

GO:0007169

GO:0007399

GO:0007411

GO:0016020

GO:0016301

GO:0016740

GO:0030425

GO:0031901

GO:0042995

GO:0048013

GO:0048731

GO:0048856

GO:0140096

Participates

as a member of

p-EPHBs [plasma membrane] (Xenopus tropicalis)

Other forms of this molecule

A0A6I8R958 [plasma membrane]

EPHB1 (?-984) [cytosol]

EPHB1 (?-984) [plasma membrane]

EPHB1 (18-?) [extracellular region]

EPHB1 [plasma membrane]

Inferred From

p-Y594,Y600-EPHB1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 594 (in Homo sapiens)

Coordinate

594

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 600 (in Homo sapiens)

Coordinate

600

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_002935121.2

ENSEMBL

ENSXETT00000103641, ENSXETG00000013722, ENSXETP00000077216

Xenbase

XB-GENE-488626

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