Reactome | rangap1 [cytosol]

rangap1 [cytosol]

Stable Identifier

R-XTR-376255

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RANGAP1, A0A6I8RNJ4

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - Mitotic Spindle Checkpoint (Xenopus tropicalis)
    - Amplification of signal from the kinetochores (Xenopus tropicalis)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Xenopus tropicalis)
        
        MAD2 associates with the Mad1 kinetochore complex (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Mad1 binds kinetochore (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Release of activated MAD2 from kinetochores (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
- Cell Cycle, Mitotic (Xenopus tropicalis)
  - M Phase (Xenopus tropicalis)
    - Mitotic Metaphase and Anaphase (Xenopus tropicalis)
      - Mitotic Anaphase (Xenopus tropicalis)
        
        Separation of Sister Chromatids (Xenopus tropicalis)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Xenopus tropicalis)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
    - Mitotic Prometaphase (Xenopus tropicalis)
      - EML4 and NUDC in mitotic spindle formation (Xenopus tropicalis)
        
        EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
      - Kinetochore capture of astral microtubules (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
      - Resolution of Sister Chromatid Cohesion (Xenopus tropicalis)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Kinetochore assembly (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        rangap1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8RNJ4

Gene Names

rangap1

Reference Genes

BioGPS Gene:100144714 rangap1

ENSEMBL:ENSXETG00000006331

Monarch:100144714 rangap1

NCBI Gene:100144714 rangap1

UCSC:A0A6I8RNJ4 rangap1

Reference Transcript

RefSeq:XM_012960590.3 rangap1

Other Identifiers

100144714

GO:0005096

GO:0005634

GO:0005829

GO:0006913

GO:0007165

GO:0031267

GO:0048471

GO:0051168

GO:0098772

Participates

as a component of

Kinetochore [cytosol] (Xenopus tropicalis)

Other forms of this molecule

rangap1 [nuclear envelope]

Inferred From

RANGAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012816044.1

ENSEMBL

ENSXETP00000082220, ENSXETT00000068241, ENSXETG00000006331

Xenbase

XB-GENE-489955

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