Reactome | hbe1.2 [extracellular region]

hbe1.2 [extracellular region]

Stable Identifier

R-XTR-2168872

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

HBB, A0A5G3HUQ0

Locations in the PathwayBrowser

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Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular response to chemical stress (Xenopus tropicalis)
    - Cytoprotection by HMOX1 (Xenopus tropicalis)
      - CO binds to free ferrohemoglobin (Xenopus tropicalis)
        
        COHb [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)
        
        COHb [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        MetHb [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferriheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - H2O2 reduces MetHb (Xenopus tropicalis)
        
        MetHb [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferriheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
  - Heme signaling (Xenopus tropicalis)
    - FeHM dissociates from MetHb (Xenopus tropicalis)
      - ApoHb [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - MetHb [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferriheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
    - H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)
      - COHb [extracellular region] (Xenopus tropicalis)
        
        ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - MetHb [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferriheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - ferrohemoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Binding and Uptake of Ligands by Scavenger Receptors (Xenopus tropicalis)
  - Scavenging of heme from plasma (Xenopus tropicalis)
    - Haptoglobin binds Hemoglobin (Xenopus tropicalis)
      - Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - Hemoglobin:Haptoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
    - Haptoglobin-related Protein binds Hemoglobin (Xenopus tropicalis)
      - Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
    - Haptoglobin:Hemoglobin binds CD163 (Xenopus tropicalis)
      - Hemoglobin:Haptoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
      - Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Xenopus tropicalis)
        
        Hemoglobin:Haptoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
    - Hemoglobin:Haptoglobin:CD163 is endocytosed (Xenopus tropicalis)
      - Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Xenopus tropicalis)
        
        Hemoglobin:Haptoglobin [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Deoxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)
        
        Oxyhemoglobin Dimer [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b:oxygen [extracellular region] (Xenopus tropicalis)
        
        Hemoglobin beta:ferroheme b [extracellular region] (Xenopus tropicalis)
        
        Homologues of HBB [extracellular region] (Xenopus tropicalis)
        
        hbe1.2 [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A5G3HUQ0

Gene Names

hbe1.2

Reference Genes

BioGPS Gene:100037901 hbe1.2

ENSEMBL:ENSXETG00000045178

KEGG:xtr:100037901 hbe1.2

Monarch:100037901 hbe1.2

NCBI Gene:100037901 hbe1.2

UCSC:A0A5G3HUQ0 hbe1.2

Reference Transcript

RefSeq:NM_001097335.2 hbe1.2

Other Identifiers

100037901

448249

448665

GO:0005344

GO:0005833

GO:0015671

GO:0019825

GO:0020037

GO:0031838

GO:0046872

GO:0048821

GO:0048856

GO:0140104

Participates

as a member of

Homologues of HBB [extracellular region] (Xenopus tropicalis)

Other forms of this molecule

hbe1.2 [cytosol]

hbe1.2 [endocytic vesicle lumen]

hbe1.2 [ficolin-1-rich granule lumen]

hbe1.2 [tertiary granule lumen]

hbe1.2 [cytosol]

Inferred From

HBB [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001090804.1

ENSEMBL

ENSXETT00000116087, ENSXETT00000119984, ENSXETG00000045178, ENSXETP00000118851, ENSXETP00000113536

Xenbase

XB-GENE-29077407

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