Reactome | col4a1 [extracellular region]

col4a1 [extracellular region]

Stable Identifier

R-XTR-2127419

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL4A1(173-1669), A0A6I8Q7J4

Locations in the PathwayBrowser

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Extracellular matrix organization (Xenopus tropicalis)

- Collagen formation (Xenopus tropicalis)
  - Assembly of collagen fibrils and other multimeric structures (Xenopus tropicalis)
    - Crosslinking of collagen fibrils (Xenopus tropicalis)
      - Collagen type IV sulfilimine cross-linking by peroxidasin (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Sulfilimine-containing collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) with or without sulfiliminyl cross-links [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
    - Formation of collagen networks (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
      - Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
- Degradation of the extracellular matrix (Xenopus tropicalis)
  - Collagen degradation (Xenopus tropicalis)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
- FN1 binds Collagen types I-V, VII (Xenopus tropicalis)
  - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
    - Collagen IV [extracellular region] (Xenopus tropicalis)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
    - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
- Integrin cell surface interactions (Xenopus tropicalis)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Xenopus tropicalis)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
- Non-integrin membrane-ECM interactions (Xenopus tropicalis)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Xenopus tropicalis)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col4a1 [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8Q7J4

Gene Names

col4a1

Reference Genes

ENSEMBL:ENSXETG00000002637

KEGG Gene (Xenopus tropicalis):100124870 col4a1

Reference Transcript

RefSeq:XM_002933018.5 col4a1

Other Identifiers

100124870

GO:0005198

GO:0005201

GO:0005581

GO:0005604

GO:0016020

GO:0030312

GO:0031012

Participates

as a component of

Other forms of this molecule

col4a1 [endoplasmic reticulum lumen]

col4a1 [extracellular region]

Inferred From

Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL4A1(173-1669) [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

XP_002933064.3

Xenbase

XB-GENE-6451485

Ensembl

ENSXETG00000002637, ENSXETP00000085053, ENSXETT00000084866, ENSXETT00000082616, ENSXETP00000064506

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