Reactome | FYN [cytosol]

FYN [cytosol]

Stable Identifier

R-XTR-200917

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

A0A6I8RSV6

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        EPHA binds TIAM1 (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - EPHA-mediated growth cone collapse (Xenopus tropicalis)
        
        NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - EPHB-mediated forward signaling (Xenopus tropicalis)
        
        EPHB phosphorylates TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Ephrin signaling (Xenopus tropicalis)
        
        EFNBs bind SFKs (Xenopus tropicalis)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        GIT1 binds bPIX (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        PAKs autophosphorylate (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        PAKs phosphorylate MLC (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        p-EFNB binds GRB4 (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Semaphorin interactions (Xenopus tropicalis)
      - CRMPs in Sema3A signaling (Xenopus tropicalis)
        
        Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Xenopus tropicalis)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Xenopus tropicalis)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Xenopus tropicalis)
        
        Fyn:pCdk5:p35 [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Xenopus tropicalis)
        
        NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Xenopus tropicalis)
        
        PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Xenopus tropicalis)
        
        Fyn:pCdk5:p35 [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Phosphorylation of CRMPs by GSK3beta (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Xenopus tropicalis)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Xenopus tropicalis)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Xenopus tropicalis)
        
        Fyn:pCdk5:p35 [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)
        
        Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Sema3A PAK dependent Axon repulsion (Xenopus tropicalis)
        
        Activation of PAK by Rac1 (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Autophosphorylation of PAK (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Xenopus tropicalis)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Xenopus tropicalis)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)

Hemostasis (Xenopus tropicalis)

- Platelet Adhesion to exposed collagen (Xenopus tropicalis)
  - GPVI binds Fyn and Lyn (Xenopus tropicalis)
    - FYN [cytosol] (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
      - FYN [cytosol] (Xenopus tropicalis)
- Platelet activation, signaling and aggregation (Xenopus tropicalis)
  - GPVI-mediated activation cascade (Xenopus tropicalis)
    - Binding of Syk tyrosine kinase (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - GPVI stimulates PI3K beta, gamma (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - SYK autophosphorylates (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - p-Y348-SYK dissociates (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Intracellular signaling by second messengers (Xenopus tropicalis)
  - PIP3 activates AKT signaling (Xenopus tropicalis)
    - Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
        
        PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
        
        Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Xenopus tropicalis)
        
        FYN,LCK [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
      - Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Xenopus tropicalis)
        
        FYN,LCK [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by SCF-KIT (Xenopus tropicalis)
    - Dimerization of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - JAK2 binds to p-KIT (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation and activation of VAV1 (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of JAK2 (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Recruitment of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Regulation of KIT signaling (Xenopus tropicalis)
      - Interaction of APS and p-KIT (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - Phosphorylation of APS (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - SHP2 interacts with p-KIT (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
    - Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
  - Signaling by VEGF (Xenopus tropicalis)
    - VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
      - FYN autophosphorylates (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
      - p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        FYN [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8RSV6

Reference Genes

BioGPS Gene:100488004

ENSEMBL:ENSXETG00000021344

KEGG:xtr:100488004

Monarch:100488004

NCBI Gene:100488004

UCSC:A0A6I8RSV6

Reference Transcript

RefSeq:XM_004914562.4

Other Identifiers

100488004

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005524

GO:0005886

GO:0007169

GO:0016301

GO:0016740

GO:0030154

GO:0046872

GO:0050852

GO:0140096

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

phospho-p-S21,Y420-FYN [cytosol]

phospho-MyrG-p-Y420-FYN-1 [plasma membrane]

phospho-p-Y420-FYN [cytosol]

Inferred From

FYN [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_004914619.2

ENSEMBL

ENSXETG00000021344, ENSXETP00000088031, ENSXETT00000097115

Xenbase

XB-GENE-6053489

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