Reactome | T-cell receptor [plasma membrane]

T-cell receptor [plasma membrane]

Stable Identifier

R-XTR-198183

Type

Complex

Species

Xenopus tropicalis

Compartment

plasma membrane

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Regulation of T cell activation by CD28 family (Xenopus tropicalis)
    - Co-inhibition by PD-1 (Xenopus tropicalis)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
  - TCR signaling (Xenopus tropicalis)
    - Generation of second messenger molecules (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma1 (Xenopus tropicalis)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Xenopus tropicalis)
        
        Activated ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
    - Phosphorylation of CD3 and TCR zeta chains (Xenopus tropicalis)
      - Activation of Lck (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
      - Inactivation of Lck by Csk (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
      - Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
    - Translocation of ZAP-70 to Immunological synapse (Xenopus tropicalis)
      - Activation of ZAP-70 (Xenopus tropicalis)
        
        Activated ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
      - Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Xenopus tropicalis)
        
        T-cell receptor [plasma membrane] (Xenopus tropicalis)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

Inferred From

T-cell receptor [plasma membrane] (Homo sapiens)

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