Reactome | nck1 [cytosol]

nck1 [cytosol]

Stable Identifier

R-XTR-197954

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

NCK1, F7BL93

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - Netrin-1 signaling (Xenopus tropicalis)
      - DCC mediated attractive signaling (Xenopus tropicalis)
        
        Activation of Cdc42 (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        Activation of Rac1 (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        DCC interacting NCK-1 (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        RhoGTPase GEF's recruited to DCC (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Xenopus tropicalis)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by PDGF (Xenopus tropicalis)
    - Downstream signal transduction (Xenopus tropicalis)
      - Nck binds to the active PDGF receptor (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
  - Signaling by VEGF (Xenopus tropicalis)
    - VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
      - CDC42:GTP binds PAK2 (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - FYN autophosphorylates (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - FYN phosphorylates PAK2 (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - PAK2 autophorylates (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - p38 MAPK activation by VEGFR (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase cycle (Xenopus tropicalis)
      - RHOU GTPase cycle (Xenopus tropicalis)
        
        RHOU binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOU effectors [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOU effectors [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
      - RHOV GTPase cycle (Xenopus tropicalis)
        
        RHOV binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOV effectors [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOV effectors [cytosol] (Xenopus tropicalis)
        
        nck1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7BL93

Gene Names

nck1

Reference Genes

BioGPS Gene:493463 nck1

ENSEMBL:ENSXETG00000022688

KEGG Gene (Xenopus tropicalis):493463 nck1

Monarch:493463 nck1

NCBI Gene:493463 nck1

Reference Transcript

Other Identifiers

493463

GO:0005737

GO:0005783

GO:0005829

GO:0006417

GO:0007010

GO:0030838

GO:0043226

GO:0065003

Participates

as a candidate of

as an input of

as a component of

as a member of

NCK1,NCK2 [cytosol] (Xenopus tropicalis)

Inferred From

NCK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017949348.1, NP_001008101.1, XP_012825788.1, XP_012825789.1

Xenbase

XB-GENE-6085807

Ensembl

ENSXETG00000022688, ENSXETP00000053525, ENSXETT00000053525

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