Reactome | sh3gl2 [cytosol]

sh3gl2 [cytosol]

Stable Identifier

R-XTR-182958

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

SH3GL2, A2VCZ4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - Clathrin-mediated endocytosis (Xenopus tropicalis)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)
      - CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
    - Cargo recognition for clathrin-mediated endocytosis (Xenopus tropicalis)
      - Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
    - Clathrin recruits PIK3C2A (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        CIN85:endophilin [cytosol] (Xenopus tropicalis)
        
        SH3GLs [cytosol] (Xenopus tropicalis)
        
        SH3GL2 dimer [cytosol] (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
  - trans-Golgi Network Vesicle Budding (Xenopus tropicalis)
    - Golgi Associated Vesicle Biogenesis (Xenopus tropicalis)
      - trans-Golgi Network Coat Assembly (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
      - trans-Golgi Network Vesicle Scission (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
    - Lysosome Vesicle Biogenesis (Xenopus tropicalis)
      - trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Xenopus tropicalis)
        
        sh3gl2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A2VCZ4

Gene Names

sh3gl2

Reference Genes

BioGPS Gene:100037852 sh3gl2

ENSEMBL:ENSXETG00000039551

KEGG:xtr:100037852 sh3gl2

Monarch:100037852 sh3gl2

NCBI Gene:100037852 sh3gl2

UCSC:A2VCZ4 sh3gl2

Reference Transcript

RefSeq:NM_001097297.1 sh3gl2

Other Identifiers

100037852

GO:0005737

GO:0005768

GO:0005769

GO:0006897

GO:0008289

GO:0016020

GO:0016192

GO:0098793

GO:0098978

Participates

as an output of

as an input of

as a component of

SH3GL2 dimer [cytosol] (Xenopus tropicalis)

Other forms of this molecule

sh3gl2 [Golgi membrane]

sh3gl2 [clathrin-coated endocytic vesicle membrane]

sh3gl2 [plasma membrane]

Inferred From

SH3GL2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001090766.1

ENSEMBL

ENSXETP00000089584, ENSXETT00000071209, ENSXETG00000039551

Xenbase

XB-GENE-1012090

Cite Us!