Reactome | psmc5 [nucleoplasm]

psmc5 [nucleoplasm]

Stable Identifier

R-XTR-174312

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

PSMC5, Q6P380

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - G1/S DNA Damage Checkpoints (Xenopus tropicalis)
    - p53-Independent G1/S DNA Damage Checkpoint (Xenopus tropicalis)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Xenopus tropicalis)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)
- Cell Cycle, Mitotic (Xenopus tropicalis)
  - Regulation of mitotic cell cycle (Xenopus tropicalis)
    - APC/C-mediated degradation of cell cycle proteins (Xenopus tropicalis)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Xenopus tropicalis)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Xenopus tropicalis)
        
        Degradation of multiubiquitinated Cdh1 (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular response to chemical stress (Xenopus tropicalis)
    - KEAP1-NFE2L2 pathway (Xenopus tropicalis)
      - Nuclear events mediated by NFE2L2 (Xenopus tropicalis)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Xenopus tropicalis)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

DNA Replication (Xenopus tropicalis)

- DNA Replication Pre-Initiation (Xenopus tropicalis)
  - Assembly of the pre-replicative complex (Xenopus tropicalis)
    - Ubiquitinated geminin is degraded by the proteasome (Xenopus tropicalis)
      - 26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional regulation by RUNX2 (Xenopus tropicalis)
      - Regulation of RUNX2 expression and activity (Xenopus tropicalis)
        
        26S proteasome degrades PolyUb-RUNX2 (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)
    - Transcriptional regulation by RUNX3 (Xenopus tropicalis)
      - Regulation of RUNX3 expression and activity (Xenopus tropicalis)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Xenopus tropicalis)
        
        26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Deubiquitination (Xenopus tropicalis)
    - Ub-specific processing proteases (Xenopus tropicalis)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Xenopus tropicalis)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)
        
        USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Xenopus tropicalis)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Hedgehog (Xenopus tropicalis)
  - Hedgehog 'on' state (Xenopus tropicalis)
    - GLI2,3 are degraded by the proteasome (Xenopus tropicalis)
      - 26S proteasome [nucleoplasm] (Xenopus tropicalis)
        
        19S regulatory particle [nucleoplasm] (Xenopus tropicalis)
        
        19S RP base [nucleoplasm] (Xenopus tropicalis)
        
        PSMC4:PSMC5 [nucleoplasm] (Xenopus tropicalis)
        
        psmc5 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6P380

Gene Names

psmc5

Reference Genes

BioGPS Gene:394988 psmc5

ENSEMBL:ENSXETG00000014234

KEGG:xtr:394988 psmc5

Monarch:394988 psmc5

NCBI Gene:394988 psmc5

UCSC:Q6P380 psmc5

Reference Transcript

RefSeq:NM_204027.2 psmc5

Other Identifiers

394988

GO:0000166

GO:0000502

GO:0005524

GO:0005634

GO:0005737

GO:0006508

GO:0008233

GO:0008540

GO:0016787

GO:0016887

GO:0030163

GO:0031531

GO:0036402

GO:0043161

GO:0140296

GO:1901800

Participates

as a component of

Other forms of this molecule

psmc5 [cytosol]

Inferred From

PSMC5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_989358.1

ENSEMBL

ENSXETG00000014234, ENSXETT00000031147, ENSXETP00000031147

Xenbase

XB-GENE-999928

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