Reactome | ap2b1 [plasma membrane]

ap2b1 [plasma membrane]

Stable Identifier

R-XTR-167690

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

AP2B1, A0A6I8S667

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - L1CAM interactions (Xenopus tropicalis)
      - Recycling pathway of L1 (Xenopus tropicalis)
        
        Phosphorylation of L1 by ERK (Xenopus tropicalis)
        
        L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
        
        pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
        
        Transport of L1 into endosomes (Xenopus tropicalis)
        
        L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - Clathrin-mediated endocytosis (Xenopus tropicalis)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)
      - CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
    - Cargo recognition for clathrin-mediated endocytosis (Xenopus tropicalis)
      - Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
    - Clathrin recruits PIK3C2A (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Xenopus tropicalis)
        
        Clathrin:AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        AP-2 complex [plasma membrane] (Xenopus tropicalis)
        
        ap2b1 [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8S667

Gene Names

ap2b1

Reference Genes

BioGPS Gene:394814 ap2b1

ENSEMBL:ENSXETG00000013480

Monarch:394814 ap2b1

NCBI Gene:394814 ap2b1

UCSC:A0A6I8S667 ap2b1

Reference Transcript

RefSeq:XM_012956660.1 ap2b1

Other Identifiers

394814

GO:0006886

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030131

GO:0030276

GO:0031410

Participates

as a component of

AP-2 complex [plasma membrane] (Xenopus tropicalis)

Other forms of this molecule

ap2b1 [endolysosome membrane]

ap2b1 [clathrin-coated endocytic vesicle membrane]

ap2b1 [cytosol]

Inferred From

AP2B1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_012812114.1

ENSEMBL

ENSXETP00000093735, ENSXETT00000090505, ENSXETG00000013480

Xenbase

XB-GENE-5871354

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