Reactome | mlst8 [cytosol]

mlst8 [cytosol]

Stable Identifier

R-XTR-165676

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

MLST8, G1K3H6

Locations in the PathwayBrowser

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Autophagy (Xenopus tropicalis)

- Macroautophagy (Xenopus tropicalis)
  - Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - MTORC1 dissociates from ULK complex (Xenopus tropicalis)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)

Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular response to starvation (Xenopus tropicalis)
    - Amino acids regulate mTORC1 (Xenopus tropicalis)
      - RRAGA,B hydrolyzes GTP (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
      - mTORC1 binds RHEB:GTP (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - TP53 Regulates Metabolic Genes (Xenopus tropicalis)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)
        
        Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- MTOR signalling (Xenopus tropicalis)
  - AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Xenopus tropicalis)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - Formation of active mTORC1 complex (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
  - mTORC1-mediated signalling (Xenopus tropicalis)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Xenopus tropicalis)
        
        mlst8 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:G1K3H6

Gene Names

mlst8

Reference Genes

BioGPS Gene:496930 mlst8

ENSEMBL:ENSXETG00000016102

Monarch:496930 mlst8

NCBI Gene:496930 mlst8

UCSC:G1K3H6 mlst8

Reference Transcript

Other Identifiers

496930

GO:0005737

GO:0005764

GO:0005765

GO:0016020

GO:0031929

GO:0031931

GO:0031932

GO:0032956

Participates

as a component of

Inferred From

MLST8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012825824.1, XP_031748480.1

ENSEMBL

ENSXETP00000035110, ENSXETG00000016102, ENSXETT00000035110

Xenbase

XB-GENE-981763

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