Reactome | APP [extracellular region]

APP [extracellular region]

Stable Identifier

R-SSC-976740

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

APP(672-711), A0A286ZTE6

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Sus scrofa)

- ECM proteoglycans (Sus scrofa)
  - AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)
    - AGRN:Beta amyloid fibril [extracellular region] (Sus scrofa)
      - Beta amyloid fibril [extracellular region] (Sus scrofa)
        
        APP(672-713), APP(672-711) [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Beta amyloid fibril [extracellular region] (Sus scrofa)
      - APP(672-713), APP(672-711) [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Advanced glycosylation endproduct receptor signaling (Sus scrofa)
    - Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)
      - AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
      - AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Sus scrofa)
    - TRAF6 mediated NF-kB activation (Sus scrofa)
      - NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        Homologues of APP(672-711) [extracellular region] (Sus scrofa)
        
        APP [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZTE6

Gene Names

APP

Reference Genes

BioGPS Gene:397663

ENSEMBL:ENSSSCG00000012022.5

Monarch:397663

NCBI Gene:397663

UCSC:A0A286ZTE6 APP

Reference Transcript

RefSeq:XM_005670302.3 APP

Other Identifiers

397663

GO:0001774

GO:0002265

GO:0002376

GO:0004867

GO:0005102

GO:0005576

GO:0005615

GO:0005634

GO:0005641

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005798

GO:0005886

GO:0005905

GO:0006355

GO:0006897

GO:0006915

GO:0007155

GO:0007219

GO:0007409

GO:0007417

GO:0007611

GO:0007612

GO:0008201

GO:0008285

GO:0009986

GO:0010468

GO:0010604

GO:0010628

GO:0010629

GO:0012505

GO:0014005

GO:0016020

GO:0016192

GO:0019899

GO:0030414

GO:0030425

GO:0030426

GO:0030546

GO:0031410

GO:0031901

GO:0032722

GO:0032731

GO:0032755

GO:0032760

GO:0034330

GO:0042802

GO:0042995

GO:0043005

GO:0043197

GO:0043198

GO:0043204

GO:0043235

GO:0045121

GO:0045202

GO:0045821

GO:0045944

GO:0046330

GO:0046872

GO:0046914

GO:0048018

GO:0048143

GO:0048169

GO:0048471

GO:0048856

GO:0050729

GO:0050808

GO:0050850

GO:0050877

GO:0051246

GO:0051247

GO:0051425

GO:0070374

GO:0098772

GO:0098815

GO:0099503

GO:0106003

GO:0120283

GO:0140677

GO:0150003

GO:1900272

GO:1900273

GO:1901224

GO:1904646

GO:1905606

GO:1905908

GO:1990000

GO:1990535

GO:2000406

Ssc.14258.1.S1_at

Participates

as a member of

Homologues of APP(672-711) [extracellular region] (Sus scrofa)

Other forms of this molecule

APP [trans-Golgi network membrane]

APP [cytosol]

APP [mitochondrial inner membrane]

APP [endosome lumen]

phospho-APP [endoplasmic reticulum lumen]

APP [endoplasmic reticulum lumen]

APP [extracellular region]

APP [platelet alpha granule lumen]

APP [extracellular region]

Inferred From

APP(672-711) [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_005670359.1

ENSEMBL

ENSSSCG00000012022, ENSSSCP00000034733, ENSSSCT00000066382

VGNC

103902

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