Reactome | ASB5 [cytosol]

ASB5 [cytosol]

Stable Identifier

R-SSC-975420

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ASB5, A0A4X1VYX4

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB5 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A4X1VYX4

Gene Names

ASB5

Reference Genes

BioGPS Gene:100511413 ASB5

ENSEMBL:ENSSSCG00000030395.4

KEGG:ssc:100511413 ASB5

Monarch:100511413 ASB5

NCBI Gene:100511413 ASB5

UCSC:A0A4X1VYX4 ASB5

Reference Transcript

Other Identifiers

100511413

GO:0005515

GO:0016020

GO:0016567

GO:0035556

GO:0045732

Participates

as a member of

Inferred From

ASB5 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013839459.1, XP_003133372.3

ENSEMBL

ENSSSCP00000034584, ENSSSCG00000030395, ENSSSCT00000048988

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