Reactome | ASB3 [cytosol]

ASB3 [cytosol]

Stable Identifier

R-SSC-975411

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ASB3, F1SQJ4

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB3 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SQJ4

Gene Names

ASB3

Reference Genes

BioGPS Gene:100518009 ASB3

ENSEMBL:ENSSSCG00000008415.5

ENSEMBL:ENSSSCG00005044969.1 ASB3

KEGG Gene (Sus scrofa):100518009 ASB3

Monarch:100518009 ASB3

NCBI Gene:100518009 ASB3

Reference Transcript

Other Identifiers

100518009

GO:0003012

GO:0003013

GO:0005515

GO:0005886

GO:0016567

GO:0023052

GO:0030315

GO:0035556

GO:0036211

GO:0036371

GO:0055117

GO:0072659

Ssc.27198.1.A1_at

Ssc.27198.2.A1_at

Participates

as a member of

Inferred From

ASB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001191971.1, XP_005653098.1

OpenTargets

ENSG00000115239

Ensembl

ENSSSCP00000008981, ENSSSCG00000008415, ENSSSCT00000009215

VGNC

97034

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