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p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
Stable Identifier
R-SSC-8878153
Type
Complex
Species
Sus scrofa
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Signaling by NODAL (Sus scrofa)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
FOXO-mediated transcription (Sus scrofa)
FOXO-mediated transcription of cell cycle genes (Sus scrofa)
FOXG1 binds FOXO:SMAD complexes (Sus scrofa)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TRIM33 monoubiquitinates SMAD4 (Sus scrofa)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Transcriptional regulation by RUNX3 (Sus scrofa)
RUNX3 regulates CDKN1A transcription (Sus scrofa)
RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by Activin (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
TRIM33 monoubiquitinates SMAD4 (Sus scrofa)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(Sus scrofa)
SMAD4 [nucleoplasm]
(Sus scrofa)
Participates
as an input of
RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)
as a component of
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Sus scrofa)
as a member of
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Sus scrofa)
Inferred From
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
(Homo sapiens)
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