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CIN85:endophilin [cytosol]
Stable Identifier
R-SSC-8875480
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by EGFR (Sus scrofa)
EGFR downregulation (Sus scrofa)
Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
CBL-mediated ubiquitination of CIN85 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGFR non-clathrin mediated endocytosis (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGFR phosphorylates EPS15 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PTPN3 dephosphorylates EPS15 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Sprouty sequesters CBL away from active EGFR (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Signaling by MET (Sus scrofa)
Negative regulation of MET activity (Sus scrofa)
CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
EPS15 and HGS bind ubiquitinated MET (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Vesicle-mediated transport (Sus scrofa)
Membrane Trafficking (Sus scrofa)
Clathrin-mediated endocytosis (Sus scrofa)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
BAR domain proteins recruit dynamin (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
Epsin family proteins bind ubiquitinated cargo (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Clathrin recruits PIK3C2A (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
CLASP proteins:cargo [plasma membrane] (Sus scrofa)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
ubiquitinated cargo [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
CIN85:endophilin [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
SH3GLs [cytosol]
(Sus scrofa)
SH3KBP1 tetramer [cytosol]
(Sus scrofa)
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
as an input of
CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)
EGFR non-clathrin mediated endocytosis (Sus scrofa)
Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)
as an output of
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)
Inferred From
CIN85:endophilin [cytosol]
(Homo sapiens)
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