Reactome | SYT2 [clathrin-coated endocytic vesicle membrane]

SYT2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-SSC-8869116

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SYT2, F1S5A0

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S5A0

Gene Names

SYT2

Reference Genes

BioGPS Gene:100511582 SYT2

ENSEMBL:ENSSSCG00000010926.5

KEGG:ssc:100511582 SYT2

Monarch:100511582 SYT2

NCBI Gene:100511582 SYT2

UCSC:F1S5A0 SYT2

Reference Transcript

Other Identifiers

100511582

GO:0000149

GO:0005509

GO:0005544

GO:0005886

GO:0016020

GO:0016192

GO:0017158

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0042584

GO:0045202

GO:0046872

GO:0061891

GO:0070382

GO:0099502

GO:1903861

GO:2000300

Ssc.12033.1.A1_at

Participates

as a component of

SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Other forms of this molecule

SYT2 [plasma membrane]

Inferred From

SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_020920224.1, XP_020920223.1

ENSEMBL

ENSSSCT00000011958, ENSSSCG00000010926, ENSSSCP00000011651

VGNC

95530

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