Reactome | CLTB [cytosol]

CLTB [cytosol]

Stable Identifier

R-SSC-8856819

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

CLTB, A0A287BFZ5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - clathrin:HSPA8:ADP [cytosol] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        clathrin triskelion [cytosol] (Sus scrofa)
        
        Clathrin light chains [cytosol] (Sus scrofa)
        
        CLTB [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BFZ5

Gene Names

CLTB

Reference Genes

BioGPS Gene:100525860 CLTB

ENSEMBL:ENSSSCG00000054091.1

KEGG:ssc:100525860 CLTB

Monarch:100525860 CLTB

NCBI Gene:100525860 CLTB

UCSC:A0A287BFZ5 CLTB

Reference Transcript

RefSeq:XM_005661470.3 CLTB

Other Identifiers

100525860

GO:0005198

GO:0005802

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0016020

GO:0016192

GO:0030125

GO:0030130

GO:0030132

GO:0030659

GO:0030672

GO:0031410

GO:0032050

GO:0060170

GO:0072583

Participates

as a member of

Clathrin light chains [cytosol] (Sus scrofa)

Other forms of this molecule

CLTB [trans-Golgi network membrane]

CLTB [clathrin-coated endocytic vesicle membrane]

CLTB [lysosomal membrane]

CLTB [plasma membrane]

Inferred From

CLTB [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005661527.2

ENSEMBL

ENSSSCG00000054091, ENSSSCT00000041232, ENSSSCP00000055507

VGNC

86788

PDB

6YAI

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