Reactome | SOCS3 [cytosol]

SOCS3 [cytosol]

Stable Identifier

R-SSC-873794

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

SOCS3, E5EZY0

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Interferon Signaling (Sus scrofa)
    - Interferon alpha/beta signaling (Sus scrofa)
      - Activation of JAK kinases (Sus scrofa)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Sus scrofa)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
    - Interferon gamma signaling (Sus scrofa)
      - Regulation of IFNG signaling (Sus scrofa)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - Transphosphorylation of JAK1 (Sus scrofa)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Sus scrofa)
        
        SOCS-1 and SOCS-3 [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-6 family signaling (Sus scrofa)
      - Interleukin-6 signaling (Sus scrofa)
        
        SOCS3 binds IL6ST (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS3 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:E5EZY0

Gene Names

SOCS3

Reference Genes

BioGPS Gene:493186 SOCS3

ENSEMBL:ENSSSCG00000036956.3

Monarch:493186 SOCS3

NCBI Gene:493186 SOCS3

UCSC:E5EZY0 SOCS3

Reference Transcript

RefSeq:XM_021066253.1 SOCS3

Other Identifiers

493186

GO:0001784

GO:0003723

GO:0005126

GO:0007165

GO:0007259

GO:0009898

GO:0009968

GO:0016567

GO:0019221

GO:0030154

GO:0030292

GO:0035198

GO:0035556

GO:0045597

GO:0046426

GO:0046627

GO:0048856

GO:0050728

GO:0060670

GO:0060674

GO:0070102

GO:0097398

GO:0098772

GO:1990830

Ssc.2827.1.S1_at

SscAffx.38.1.S1_at

Participates

as a member of

as an input of

as a component of

Inferred From

SOCS3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_020921912.1

ENSEMBL

ENSSSCT00000054084, ENSSSCP00000051672, ENSSSCG00000036956

VGNC

99052

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