Reactome | RPL26 [cytosol]

RPL26 [cytosol]

Stable Identifier

R-SSC-72436

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPL26, I3L7Y1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)
- rRNA processing (Sus scrofa)
  - rRNA processing in the nucleus and cytosol (Sus scrofa)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Sus scrofa)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL26,RPL26L1 [cytosol] (Sus scrofa)
        
        RPL26 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3L7Y1

Gene Names

RPL26

Reference Genes

BioGPS Gene:100627662 RPL26

ENSEMBL:ENSSSCG00000028850.4

KEGG:ssc:100627662 RPL26

Monarch:100627662 RPL26

NCBI Gene:100627662 RPL26

UCSC:I3L7Y1 RPL26

Reference Transcript

Other Identifiers

100627662

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0015934

GO:0022625

GO:0031090

GO:0042273

GO:1990904

Ssc.6967.1.A1_at

Participates

as a member of

RPL26,RPL26L1 [cytosol] (Sus scrofa)

Inferred From

RPL26 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001230387.1, XP_020921824.1

ENSEMBL

ENSSSCT00000024076, ENSSSCG00000028850, ENSSSCP00000020139

PDB

3J7O, 3J7P

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