Reactome | LOC100525613 [cytosol]

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - Mitotic Spindle Checkpoint (Sus scrofa)
    - Amplification of signal from the kinetochores (Sus scrofa)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
        
        MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Mad1 binds kinetochore (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Release of activated MAD2 from kinetochores (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Metaphase and Anaphase (Sus scrofa)
      - Mitotic Anaphase (Sus scrofa)
        
        Separation of Sister Chromatids (Sus scrofa)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Separation of sister chromatids (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - Mitotic Prometaphase (Sus scrofa)
      - EML4 and NUDC in mitotic spindle formation (Sus scrofa)
        
        EML4 recruits NUDC to mitotic spindle (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Kinetochore capture of astral microtubules (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Resolution of Sister Chromatid Cohesion (Sus scrofa)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Kinetochore assembly (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Translation (Sus scrofa)
  - Eukaryotic Translation Initiation (Sus scrofa)
    - Cap-dependent Translation Initiation (Sus scrofa)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Sus scrofa)
        
        Translation initiation complex formation (Sus scrofa)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Formation of a pool of free 40S subunits (Sus scrofa)
        
        Release of 40S and 60S subunits from the 80S ribosome (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        40S:eIF3:eIF1A [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Formation of the ternary complex, and subsequently, the 43S complex (Sus scrofa)
        
        Formation of the 43S pre-initiation complex (Sus scrofa)
        
        40S:eIF3:eIF1A [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Sus scrofa)
        
        The 60S subunit joins the translation initiation complex (Sus scrofa)
        
        40S:Met-tRNAi:mRNA [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        eIF5B:GTP is hydrolyzed and released (Sus scrofa)
        
        80S:Met-tRNAi:mRNA [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - Ribosomal scanning and start codon recognition (Sus scrofa)
        
        Ribosomal scanning (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Start codon recognition (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Sus scrofa)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        43S complex [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
  - Ribosome-associated quality control (Sus scrofa)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Sus scrofa)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Sus scrofa)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Sus scrofa)
        
        ABCE1:ADP:40S ribosomal subunit [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Sus scrofa)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Sus scrofa)
      - RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Sus scrofa)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        K63polyUb-80S ribosome [cytosol] (Sus scrofa)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Sus scrofa)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        K63polyUb-80S ribosome [cytosol] (Sus scrofa)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Sus scrofa)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        K63polyUb-80S ribosome [cytosol] (Sus scrofa)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Sus scrofa)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Sus scrofa)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
  - SRP-dependent cotranslational protein targeting to membrane (Sus scrofa)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)
      - SRP:polypeptide+signal:ribosome [cytosol] (Sus scrofa)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        40S ribosomal complex [cytosol] (Sus scrofa)
        
        RPS27,RPS27L [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase Effectors (Sus scrofa)
      - RHO GTPases Activate Formins (Sus scrofa)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Homologues of RPS27 [cytosol] (Sus scrofa)
        
        LOC100525613 [cytosol] (Sus scrofa)