Reactome | SRSF1 [nucleoplasm]

SRSF1 [nucleoplasm]

Stable Identifier

R-SSC-72031

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

SRSF1, Q3YLA6

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Formation of pre-mRNPs (Sus scrofa)
    - Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
      - shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
      - Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
  - Transport of Mature Transcript to Cytoplasm (Sus scrofa)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Sus scrofa)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
  - mRNA 3'-end processing (Sus scrofa)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Spliced mRNP [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
    - mRNA Polyadenylation (Sus scrofa)
      - Core CPA complex binds capped pre-mRNA (Sus scrofa)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - PP1 dephosphorylates RNA Pol II (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - RBBP6 activates CPSF complex (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
  - mRNA Splicing (Sus scrofa)
    - mRNA Splicing - Major Pathway (Sus scrofa)
      - Formation of the Spliceosomal C complex containing intron lariat (Sus scrofa)
        
        Spliceosomal B* complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Spliceosomal C complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal C* complex (Sus scrofa)
        
        Spliceosomal C complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal E complex (Sus scrofa)
        
        Spliceosomal E complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        Spliceosomal P complex [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Sus scrofa)
        
        Spliceosomal P complex [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        Alternative Splicing Factors [nucleoplasm] (Sus scrofa)
        
        shuttling SRSFs [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
    - mRNA Splicing - Minor Pathway (Sus scrofa)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        post exon ligation complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC B Complex (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC C complex (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        SRSF1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q3YLA6

Gene Names

SRSF1

Reference Genes

BioGPS Gene:654327 SRSF1

ENSEMBL:ENSSSCG00000017626

KEGG:ssc:654327 SRSF1

Monarch:654327 SRSF1

NCBI Gene:654327 SRSF1

UCSC:Q3YLA6 SRSF1

Reference Transcript

RefSeq:NM_001038007.1 SRSF1

Other Identifiers

654327

GO:0000380

GO:0000395

GO:0001701

GO:0003012

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005737

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0023019

GO:0034504

GO:0035145

GO:0043484

GO:0044547

GO:0048255

GO:0048856

GO:0050733

GO:0060048

GO:0065003

GO:0071013

GO:0097398

GO:0097400

GO:0110012

Ssc.31065.1.A1_at

Ssc.7576.2.A1_at

Ssc.7576.3.S1_at

Participates

as a component of

as a member of

shuttling SRSFs [nucleoplasm] (Sus scrofa)

Inferred From

SRSF1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001033096.1

ENSEMBL

ENSSSCG00000017626, ENSSSCP00000057414, ENSSSCT00000043811

VGNC

99084

Cite Us!