Reactome | CSTF2 [nucleoplasm]

CSTF2 [nucleoplasm]

Stable Identifier

R-SSC-72003

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

CSTF2, I3LE23

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Polymerase II Transcription Termination (Sus scrofa)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)
      - CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Sus scrofa)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - mRNA 3'-end processing (Sus scrofa)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)
      - Spliced mRNP [nucleoplasm] (Sus scrofa)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
    - mRNA Polyadenylation (Sus scrofa)
      - Core CPA complex binds capped pre-mRNA (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - Formation of the CSTF complex (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - Formation of the core cleavage and polyadenylation complex (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Sus scrofa)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - PP1 dephosphorylates RNA Pol II (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Sus scrofa)
        
        CPA complex [nucleoplasm] (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        CPA complex [nucleoplasm] (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - RBBP6 activates CPSF complex (Sus scrofa)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        CPA complex [nucleoplasm] (Sus scrofa)
        
        Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Sus scrofa)
        
        Ub-K63-CPA complex [nucleoplasm] (Sus scrofa)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Sus scrofa)
        
        CSTF hexamer [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
- Processing of Capped Intronless Pre-mRNA (Sus scrofa)
  - Processing of Intronless Pre-mRNAs (Sus scrofa)
    - Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Sus scrofa)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
    - Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)
      - CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Sus scrofa)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)
      - CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Sus scrofa)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
    - Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)
      - CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        CSTF heterotrimer [nucleoplasm] (Sus scrofa)
        
        CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)
        
        CSTF2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LE23

Gene Names

CSTF2

Reference Genes

BioGPS Gene:100515986 CSTF2

ENSEMBL:ENSSSCG00000012486.6

Monarch:100515986 CSTF2

NCBI Gene:100515986 CSTF2

UCSC:I3LE23 CSTF2

Reference Transcript

RefSeq:XM_003360388.4 CSTF2

Other Identifiers

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0016071

GO:0016604

GO:0031124

GO:0071920

Ssc.21222.1.A1_at

Ssc.3557.1.A1_at

Participates

as a member of

CSTF2,CSTF2T [nucleoplasm] (Sus scrofa)

Inferred From

CSTF2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003360436.1

ENSEMBL

ENSSSCG00000012486, ENSSSCP00000022308, ENSSSCT00000027214

VGNC

87050

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