Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PSMC1 [cytosol]
Stable Identifier
R-SSC-68768
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
PSMC1, F2Z5J1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
G1/S DNA Damage Checkpoints (Sus scrofa)
p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
p53-Dependent G1 DNA Damage Response (Sus scrofa)
Stabilization of p53 (Sus scrofa)
Autodegradation of the E3 ubiquitin ligase COP1 (Sus scrofa)
Proteasome mediated degradation of COP1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
G2/M Checkpoints (Sus scrofa)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
M Phase (Sus scrofa)
Mitotic Metaphase and Anaphase (Sus scrofa)
Mitotic Anaphase (Sus scrofa)
Separation of Sister Chromatids (Sus scrofa)
Degradation of multiubiquitinated Securin (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Mitotic G2-G2/M phases (Sus scrofa)
G2/M Transition (Sus scrofa)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Sus scrofa)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
The role of GTSE1 in G2/M progression after G2 checkpoint (Sus scrofa)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Regulation of mitotic cell cycle (Sus scrofa)
APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Sus scrofa)
Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of Securin (Sus scrofa)
Degradation of multiubiquitinated Securin (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Sus scrofa)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Sus scrofa)
Degradation multiubiquitinated Cyclin A (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
S Phase (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Ubiquitin-dependent degradation of Cyclin D (Sus scrofa)
Proteasome mediated degradation of Cyclin D1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Cell-Cell communication (Sus scrofa)
Cell junction organization (Sus scrofa)
Cell-cell junction organization (Sus scrofa)
Adherens junctions interactions (Sus scrofa)
Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
Regulation of Expression and Function of Type I Classical Cadherins (Sus scrofa)
Regulation of CDH1 Expression and Function (Sus scrofa)
Regulation of CDH1 Function (Sus scrofa)
Degradation of CDH1 (Sus scrofa)
Proteasome-dependent degradation of ubiquitinated CDH1 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
KEAP1-NFE2L2 pathway (Sus scrofa)
26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Circadian clock (Sus scrofa)
Degradation of CRY and PER proteins (Sus scrofa)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
DNA Replication (Sus scrofa)
Synthesis of DNA (Sus scrofa)
Switching of origins to a post-replicative state (Sus scrofa)
CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Orc1 removal from chromatin (Sus scrofa)
Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional regulation by RUNX1 (Sus scrofa)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Sus scrofa)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing-Cross presentation (Sus scrofa)
Cross-presentation of soluble exogenous antigens (endosomes) (Sus scrofa)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Proteasomal cleavage of substrate (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Regulation of PD-L1(CD274) expression (Sus scrofa)
Regulation of PD-L1(CD274) Post-translational modification (Sus scrofa)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) (Sus scrofa)
Proteasomal degradation of polyUb-p-S195-CD274 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
Activation of NF-kappaB in B cells (Sus scrofa)
Ubiquitinated IkB is degraded (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
TNFR2 non-canonical NF-kB pathway (Sus scrofa)
26Sproteasome degrades K48polyUb-NIK (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
NIK-->noncanonical NF-kB signaling (Sus scrofa)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Dectin-1 mediated noncanonical NF-kB signaling (Sus scrofa)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of polyamines (Sus scrofa)
Regulation of ornithine decarboxylase (ODC) (Sus scrofa)
26S proteosome degrades ODC holoenzyme complex (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Metabolism of RNA (Sus scrofa)
Regulation of mRNA stability by proteins that bind AU-rich elements (Sus scrofa)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Sus scrofa)
AUF1:mRNA complex is degraded (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Sus scrofa)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)
Deglycosylation complex [endoplasmic reticulum membrane] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Deubiquitination (Sus scrofa)
UCH proteinases (Sus scrofa)
ADRM1 binds 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ADRM1:26S proteasome:UCHL5 [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
ADRM1:26S proteaseome binds USP14 (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ADRM1:26S proteasome:USP14 [cytosol] (Sus scrofa)
ADRM1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Neddylation (Sus scrofa)
26S proteasome degrades HIFalpha (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Proteasome assembly (Sus scrofa)
Formation of the 19S regulatory particle precursor (Sus scrofa)
19S RP base precursor [cytosol] (Sus scrofa)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
19S RP precursor [cytosol] (Sus scrofa)
19S RP base precursor [cytosol] (Sus scrofa)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
PSMC2 binds PSMC1 (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
PSMD5 and PSMD2 bind PSMC2:PSMC1 (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Translation (Sus scrofa)
Ribosome-associated quality control (Sus scrofa)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Sus scrofa)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
PTEN Regulation (Sus scrofa)
Regulation of PTEN stability and activity (Sus scrofa)
Proteasome degrades polyubiquitinated PTEN (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
Regulation of RAS by GAPs (Sus scrofa)
NF1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
MAPK6/MAPK4 signaling (Sus scrofa)
MAPK6 is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
Degradation of GLI1 by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
GLI3 is processed to GLI3R by the proteasome (Sus scrofa)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Hedgehog 'on' state (Sus scrofa)
ub-GLI is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Hedgehog ligand biogenesis (Sus scrofa)
Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
PCP/CE pathway (Sus scrofa)
Asymmetric localization of PCP proteins (Sus scrofa)
PRICKLE1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
TCF dependent signaling in response to WNT (Sus scrofa)
Degradation of AXIN (Sus scrofa)
Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Degradation of DVL (Sus scrofa)
Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
Transport of small molecules (Sus scrofa)
ABC-family protein mediated transport (Sus scrofa)
misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)
26S proteasome [cytosol] (Sus scrofa)
19S regulatory particle [cytosol] (Sus scrofa)
19S RP base [cytosol] (Sus scrofa)
PSMC2:PSMC1:PSMD2 [cytosol] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
PSMC1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F2Z5J1
Gene Names
PSMC1
Reference Genes
BioGPS Gene:100155274 PSMC1
ENSEMBL:ENSSSCG00000002433.4
KEGG:ssc:100155274 PSMC1
Monarch:100155274 PSMC1
NCBI Gene:100155274 PSMC1
UCSC:F2Z5J1 PSMC1
Reference Transcript
RefSeq:NM_001244151.1 PSMC1
Other Identifiers
100155274
GO:0000166
GO:0000502
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006508
GO:0008233
GO:0008540
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0036402
GO:0043161
GO:1901800
Ssc.1911.1.A1_at
Participates
as an input of
PSMC2 binds PSMC1 (Sus scrofa)
as a component of
Deglycosylation complex [endoplasmic reticulum membrane] (Sus scrofa)
PSMC2:PSMC1 [cytosol] (Sus scrofa)
Other forms of this molecule
PSMC1 [nucleoplasm]
Inferred From
PSMC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001231080.1
ENSEMBL
ENSSSCT00000002703
,
ENSSSCP00000002634
,
ENSSSCG00000002433
VGNC
91912
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
