Reactome | CDC6 [nucleoplasm]

CDC6 [nucleoplasm]

Stable Identifier

R-SSC-68542

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

CDC6, F1RXE3

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Activation of claspin (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - Loading of claspin onto DNA during replication origin firing (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Cdt1 is displaced from the pre-replicative complex (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
        
        Cdc6 protein is phosphorylated by CDK (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - Cdt1 is displaced from the pre-replicative complex (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase epsilon binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - CDC6 association with the ORC:origin complex (Sus scrofa)
      - CDC6 association with ORC(1-6) at replication origins (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        CDC6:MCM8 [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
      - MCM8 binds CDC6 (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        CDC6:MCM8 [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
      - Cdc6 protein is phosphorylated by CDK (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RXE3

Gene Names

CDC6

Reference Genes

BioGPS Gene:100522031 CDC6

ENSEMBL:ENSSSCG00000017471.4

KEGG:ssc:100522031 CDC6

Monarch:100522031 CDC6

NCBI Gene:100522031 CDC6

UCSC:F1RXE3 CDC6

Reference Transcript

Other Identifiers

100522031

GO:0000166

GO:0000922

GO:0003682

GO:0003688

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0006260

GO:0006270

GO:0030071

GO:0032467

GO:0033314

GO:0043226

GO:0045171

GO:0051233

GO:0051301

GO:0051984

GO:0072686

GO:0120283

Ssc.11879.1.A1_at

Ssc.2230.1.A1_at

Ssc.2230.2.S1_at

Ssc.2230.3.S1_at

Participates

as an input of

as a component of

Other forms of this molecule

CDC6 [cytosol]

phospho-CDC6 [cytosol]

phospho-CDC6 [nucleoplasm]

Inferred From

CDC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003131519.1, XP_020922681.1

ENSEMBL

ENSSSCG00000017471, ENSSSCT00000019020, ENSSSCP00000018515

VGNC

86464

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