Reactome | GNB5 [cytosol]

Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - Signal amplification (Sus scrofa)
    - ADP signalling through P2Y purinoceptor 12 (Sus scrofa)
      - Gi activation by P2Y purinoceptor 12 (Sus scrofa)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
    - Thromboxane signalling through TP receptor (Sus scrofa)
      - G13 activation by TP receptor (Sus scrofa)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - Gq activation by TP receptor (Sus scrofa)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        G protein-GTP [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
  - Thrombin signalling through proteinase activated receptors (PARs) (Sus scrofa)
    - Thrombin-activated PARs activate Gq (Sus scrofa)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Sus scrofa)
        
        G protein-GTP [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Protein folding (Sus scrofa)
  - Chaperonin-mediated protein folding (Sus scrofa)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Sus scrofa)
      - ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - PDCL promotes G-protein beta 5 folding (Sus scrofa)
        
        GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)
        
        GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Sus scrofa)
        
        GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - Release of GNB5:RGS dimers from CCT/TRiC (Sus scrofa)
        
        GNB5:(RGS7,RGS9,(RGS6,RGS11)) [plasma membrane] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Sus scrofa)
        
        GNB5:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Sus scrofa)
        
        Unfolded G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)

Neuronal System (Sus scrofa)

- Potassium Channels (Sus scrofa)
  - Inwardly rectifying K+ channels (Sus scrofa)
    - G protein gated Potassium channels (Sus scrofa)
      - Activation of G protein gated Potassium channels (Sus scrofa)
        
        Activation of GIRK/Kir3 Channels (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - GABA receptor activation (Sus scrofa)
      - GABA B receptor activation (Sus scrofa)
        
        Activation of GABAB receptors (Sus scrofa)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Sus scrofa)
        
        Activation of GIRK/Kir3 Channels (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - Opioid Signalling (Sus scrofa)
        
        G-protein activation (Sus scrofa)
        
        The receptor:G-protein complex binds GTP (Sus scrofa)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Sus scrofa)
        
        G protein-GTP [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        The receptor:G-protein complex releases GDP (Sus scrofa)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Sus scrofa)
        
        G protein-GDP complex [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - Opsins act as GEFs for G alpha-t (Sus scrofa)
        
        G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Sus scrofa)
        
        G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Sus scrofa)
        
        G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        G protein-GTP [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
    - G alpha (z) signalling events (Sus scrofa)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gz (active) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
    - G-protein beta:gamma signalling (Sus scrofa)
      - G beta:gamma signalling through CDC42 (Sus scrofa)
        
        CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
      - G beta:gamma signalling through PI3Kgamma (Sus scrofa)
        
        G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
- Signaling by WNT (Sus scrofa)
  - Beta-catenin independent WNT signaling (Sus scrofa)
    - Ca2+ pathway (Sus scrofa)
      - WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Sus scrofa)
        
        G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
        
        G-protein beta subunit [cytosol] (Sus scrofa)
        
        GNB5 [cytosol] (Sus scrofa)