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PDPK1 [plasma membrane]
Stable Identifier
R-SSC-61459
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
A0A286ZV67
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Expression and Degradation (Sus scrofa)
Regulation of TP53 Degradation (Sus scrofa)
PDPK1 phosphorylates SGK1 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Costimulation by the CD28 family (Sus scrofa)
CD28 co-stimulation (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Activation of IKK complex (Sus scrofa)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Activation of TAK1-TAB2 complex (Sus scrofa)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Auto-ubiquitination of TRAF6 (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Interaction of Bcl10 to CARMA1 (Sus scrofa)
Bcl10 bound to CARMA1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Oligomerization of Bcl10 (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Oligomerization of CARMA1 (Sus scrofa)
Activated CARMA1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Phosphorylation of Bcl10 (Sus scrofa)
Bcl10 bound to CARMA1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Phosphorylation of CARMA1 (Sus scrofa)
Activated CARMA1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
CARMA1 bound to PDK1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Phosphorylation of PKC theta (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Translocation of CARMA1 to Plasma membrane (Sus scrofa)
CARMA1 bound to PDK1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Translocation of PDK1 to Plasma membrane (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Translocation of TRAF6 to CBM complex (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
Translocation of PDK1 to Plasma membrane (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
PDPK1 binds PIP2 (Sus scrofa)
PDPK1:PIP2 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1 phosphorylates SGK1 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Extra-nuclear estrogen signaling (Sus scrofa)
Estrogen-stimulated signaling through PRKCZ (Sus scrofa)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
Activation of AKT2 (Sus scrofa)
PDPK1 binds PIP3 (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1 phosphorylates AKT2 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
Activation of AKT2 (Sus scrofa)
PDPK1 binds PIP3 (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
PDPK1 phosphorylates AKT2 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFR2 mediated cell proliferation (Sus scrofa)
PDK1 phosphorylates PKC (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
VEGFR2 mediated vascular permeability (Sus scrofa)
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases activate PKNs (Sus scrofa)
PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1 [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZV67
Reference Genes
ENSEMBL:ENSSSCG00000037719.3
Other Identifiers
100192445
GO:0000166
GO:0002376
GO:0003323
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006972
GO:0007173
GO:0008286
GO:0010594
GO:0010667
GO:0012501
GO:0014069
GO:0016004
GO:0016192
GO:0016477
GO:0016740
GO:0019722
GO:0023052
GO:0030154
GO:0030512
GO:0031410
GO:0032869
GO:0034122
GO:0035556
GO:0036211
GO:0042995
GO:0043122
GO:0043226
GO:0043274
GO:0043304
GO:0043536
GO:0045766
GO:0048009
GO:0048856
GO:0048870
GO:0051281
GO:0055065
GO:0055085
GO:0071364
GO:0072659
GO:0097191
GO:0098542
GO:0098772
GO:0140096
GO:1903078
GO:1903672
GO:1905564
GO:2000352
Ssc.10367.1.A1_at
Ssc.2809.1.S1_at
Ssc.30774.1.S1_at
Participates
as an input of
PDPK1 binds PIP3 (Sus scrofa)
as a component of
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP2 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
Other forms of this molecule
PDPK1 [cytosol]
Inferred From
AKT1/PDK1 [plasma membrane]
(Homo sapiens)
PDPK1 [plasma membrane]
(Homo sapiens)
Cross References
Ensembl
ENSSSCT00000054591
,
ENSSSCP00000035547
,
ENSSSCG00000037719
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