Reactome | MCFD2 [endoplasmic reticulum membrane]

MCFD2 [endoplasmic reticulum membrane]

Stable Identifier

R-SSC-5689470

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

endoplasmic reticulum membrane

Synonyms

MCFD2, K7GQY4

Locations in the PathwayBrowser

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Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPII-mediated vesicle transport (Sus scrofa)
        
        Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Loss of SAR1B GTPase (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Cargo concentration in the ER (Sus scrofa)
        
        Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPII-mediated vesicle transport (Sus scrofa)
      - Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
      - Loss of SAR1B GTPase (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
      - SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
      - Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
    - Cargo concentration in the ER (Sus scrofa)
      - Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
      - Inner coat assembly and cargo binding (Sus scrofa)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Sus scrofa)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Sus scrofa)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)
        
        MCFD2 [endoplasmic reticulum membrane] (Sus scrofa)