Reactome | phospho-p-S446,T599,S602,S729 BRAF [cytosol]

phospho-p-S446,T599,S602,S729 BRAF [cytosol]

Stable Identifier

R-SSC-5672676

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

A0A286ZVY2

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        Dissociation of RAS:RAF complex (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        activated RAF homo/heterodimer [cytosol] (Sus scrofa)
        
        activated RAF monomer [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Sus scrofa)
        
        activated RAF homo/heterodimer [cytosol] (Sus scrofa)
        
        activated RAF monomer [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Sus scrofa)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAF phosphorylates MAP2K dimer (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        activated RAF homo/heterodimer [cytosol] (Sus scrofa)
        
        activated RAF monomer [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        activated RAF homo/heterodimer [cytosol] (Sus scrofa)
        
        activated RAF monomer [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
      - Negative regulation of MAPK pathway (Sus scrofa)
        
        PEBP1 binds activated RAF1 (Sus scrofa)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Sus scrofa)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        PP2A dephosphorylates RAF1 (Sus scrofa)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        PP5 dephosphorylates RAF1 S338 (Sus scrofa)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
      - RAF activation (Sus scrofa)
        
        "Activator" RAF:YWHAB dimer binds RAS:GTP (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Phosphorylation of RAF (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Raf dimer inhibitors bind RAF heterodimers (Sus scrofa)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Sus scrofa)
        
        'activator' RAF:YWHAB dimer [cytosol] (Sus scrofa)
        
        'activator' RAFs [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - Signalling to ERKs (Sus scrofa)
        
        Prolonged ERK activation events (Sus scrofa)
        
        Frs2-mediated activation (Sus scrofa)
        
        Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Sus scrofa)
        
        RAP1:GTP:activated BRAF dimer [endosome membrane] (Sus scrofa)
        
        p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)
        
        phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZVY2

Reference Genes

ENSEMBL:ENSSSCG00000016494.5

UCSC:A0A286ZVY2

Other Identifiers

100514612

GO:0000165

GO:0000166

GO:0002318

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004709

GO:0005509

GO:0005524

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005886

GO:0005929

GO:0006468

GO:0007155

GO:0007165

GO:0007173

GO:0008542

GO:0010628

GO:0010764

GO:0010828

GO:0016079

GO:0016192

GO:0016301

GO:0016740

GO:0030154

GO:0030878

GO:0033077

GO:0034446

GO:0034451

GO:0035019

GO:0036064

GO:0042127

GO:0042802

GO:0043005

GO:0043066

GO:0043149

GO:0043226

GO:0043367

GO:0043368

GO:0043369

GO:0043524

GO:0044297

GO:0045580

GO:0046632

GO:0046872

GO:0048538

GO:0048679

GO:0048680

GO:0048856

GO:0050772

GO:0050852

GO:0051496

GO:0060291

GO:0060323

GO:0060324

GO:0070371

GO:0070374

GO:0071277

GO:0071466

GO:0072577

GO:0090150

GO:0097110

GO:0098793

GO:0098794

GO:0098978

GO:0099170

GO:0140096

GO:1900026

GO:2000301

GO:2000352

Ssc.6325.1.A1_at

Participates

as a member of

activated RAF monomer [cytosol] (Sus scrofa)

as a component of

p-S445,T599,T602,S729 B-Raf complex [cytosol] (Sus scrofa)

as a candidate of

'activator' RAFs [cytosol] (Sus scrofa)

Other forms of this molecule

BRAF [cytosol]

phospho-hyperphosphorylated BRAF [plasma membrane]

phospho-p-S365,S446,S729 BRAF [cytosol]

phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]

phospho-p-S446,S729-BRAF [cytosol]

Inferred From

p-S446,T599,S602,S729 BRAF [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 446 (in Homo sapiens)

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729 (in Homo sapiens)

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599 (in Homo sapiens)

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602 (in Homo sapiens)

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ENSEMBL

ENSSSCT00000036816, ENSSSCP00000035615, ENSSSCG00000016494

VGNC

85866

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