Reactome | LOC100737977 [plasma membrane]

LOC100737977 [plasma membrane]

Stable Identifier

R-SSC-5633393

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

TNFRSF10A, F1RM98

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Sus scrofa)

- Apoptosis (Sus scrofa)
  - Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
    - Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
      - Dimerization of procaspase-8 (Sus scrofa)
        
        TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
      - Regulation by c-FLIP (Sus scrofa)
        
        Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8 [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
- Regulated Necrosis (Sus scrofa)
  - RIPK1-mediated regulated necrosis (Sus scrofa)
    - Regulation of necroptotic cell death (Sus scrofa)
      - CASP8 activity is inhibited (Sus scrofa)
        
        FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)
        
        DISC:procaspase-8 [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8 [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)
        
        DISC:procaspase-8 [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Sus scrofa)
        
        DISC:procaspase-8 [plasma membrane] (Sus scrofa)
        
        DISC [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Sus scrofa)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Sus scrofa)
        
        LOC100737977 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RM98

Gene Names

LOC100737977

Reference Genes

BioGPS Gene:100624226 LOC100737977

ENSEMBL:ENSSSCG00000009633

KEGG Gene (Sus scrofa):100624226 LOC100737977

Monarch:100624226 LOC100737977

NCBI Gene:100624226 LOC100737977

Reference Transcript

Other Identifiers

100624226

100737977

GO:0003674

GO:0005575

GO:0005886

GO:0006915

GO:0007165

GO:0008150

GO:0008219

GO:0009986

GO:0016020

GO:0016021

GO:0036462

GO:0043065

GO:0045569

Ssc.8031.1.A1_at

Participant Of

input

hasComponent

Other forms of this molecule

LOC100737977 [plasma membrane]

Inferred From

TNFRSF10A [plasma membrane] (Homo sapiens)

TNFRSF10A,TNFRSF10B [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005670487.1, XP_005670480.1

Ensembl

ENSSSCT00000010560, ENSSSCG00000009633, ENSSSCP00000010284

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